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Test Code 5028 Smooth Muscle Antibodies, Serum

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Methodology

Indirect Immunofluorescence

Testing Algorithm:

If smooth muscle antibody is positive, smooth muscle antibody titer will be performed, at an additional charge.

Literature References:

1. Package insert: ImmuGlo autoantibody test system I. IMMCO Diagnostics, Inc. 8/2002.
2. Henry JB. Clinical diagnosis and management by laboratory methods, 20th ed. Philadelphia: Saunders, 2001;270.

Specimen Requirements

Specimen Type: Serum

Container/Type: Plain red top

Specimen Volume: Full tube

 

Day(s) Test Set Up

Wednesday

Cut-off time: 0800

Turnaround Time:
STAT: not available
Routine: results available the day of testing

Reference Values

Negative: Titers equal to or less than 1:20
Titers greater than 1:20 may be present in acute viral hepatitis, lupoid hepatitis, infectious mononucleosis, and malignancy.
Titer equal to or greater than 1:80 highly suggestive of chronic active hepatitis

 

Literature References:

1. Alvarez F, Berg P, Bianchi F, Bianchi L, Burroughs AK, Cancado EL, et al. International autoimmune hepatitis group report: a review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-38.

2. Czaja AJ, Norman GL. Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota and INOVA Diagnostics, San Diego, California. Autoantibodies in the diagnosis and management of liver disease. J Clin Gastroenterol 2003;37:315-29.

Test Classification and CPT Coding

86255-Fluorescent antibody screen
86256-Fluorescent antibody titer (if appropriate)

Additional Information

For BJH Laboratory Use Only

Alternate Tube: SST Red top

Laboratory Processing Instructions:

Test performed in BJH Immunology. Spin blood as soon as possible and separate serum from the clot. Store serum frozen at -20° C.

Note: #5027 Mitochondrial Antibodies, Serum is performed on the same slide. If positive, results will be reported at no charge. Titer will not be performed.

Specimen Transport Temperature

Ambient

LOINC Code Information

Name LOINC Code
Smooth Muscle Antibodies, Serum 26971-2