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Test Code 76480010 Epstein-Barr Viral Antibody Panel, Serum

Performing Laboratory

Barnes-Jewish Hospital Lab

Methodology

Multiplex Flourescent Immunoassay

Testing for Epstein-Barr Viral Capsid IgG, Epstein-Barr Viral Capsid IgM and Epstein-Barr Nuclear Antigen IgG

Literature Reference:

1. EBV IgG and EBV IgM package insert. Bio-Rad Laboratories, Inc. 3/2012

2. Stevens CD. Clinical immunology and serology: a laboratory perspective. 2nd ed. Davis, 2003:330-2

3. Henry JB. Clinical diagnosis and management by laboratory methods, 20th ed. Saunders, 2001:593-5, 56-7

4. Straus SE, Cohen JI, Tosato G, Meier J. Epstein-Barr virus infections: biology, pathogenesis and management (NIH Conference), Ann Intern Med 1993; 118:45-58

Specimen Requirements

Specimen Type: Serum only

Container/Tube: Plain red top, red/grey separator

Specimen Volume: Full tube, minimum 1mL of serum

Day(s) Test Set Up

Monday - Sunday

Cut-off time: 1300

Turnaround Time:

STAT: not available

Routine: result available to day of testing

Reference Values

See individual tests for reference values for EBV VCA IgG and EBV VCA IgM

EBV NA

Negative

No detectable IgG antibody to EBV Nuclear Antigen. 

Equivocal

Uncertain immune status, suggest sending additional specimen.

Positive

Indicates the presence of detectable IgG antibody to EBV Nuclear Antigen.  This indicates a current or previous infection with EBV. Follow the Interpretation Algorithm for the EBV Panel.

 

Test Classification and CPT Coding

86665 Epstein-Barr virus, viral capsid IgG

86665 Epstein-Barr virus, viral capsid IgM

86664 Epstein-Barr virus, nuclear antigen IgG

Specimen Transport Temperature

Ambient

EBV PANEL Interpretation Algorithm

 

EBV VCA IgG  

EBV VCA IgM

EBV NA

Interpretation

Neg

Neg

Neg

No Previous Exposure

Pos

Pos

Neg

Recent Infection

Pos

Neg

Pos

Past Infection

Pos                        

Pos

Pos

Past Infection

Pos

Neg

Neg

Results indicate infection with EBV at some time (VCA IgG positive). However, the time of the infection cannot be predicted (ie recent or past) since antibodies to EBNA usually develop after primary infection (recent) or, alternatively, approximately 5% to 10% of patients with EBV never develop antibodies to EBNA (past).

All other result combinations including Equivocal.

Refer to Interp Data for individual antibody results.

 

LOINC Code Information

Epstein Barr Virus, VCA IgG

5157-3

Epstein Barr Virus, VCA IgM

5159-9

Epstein Barr Virus, NA IgG

30083-0