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Test Code 1760 Theophylline, Plasma

Performing Laboratory

Barnes-Jewish Hospital Laboratory


Kinetic interaction of microparticles in solution (KIMS)

Literature References:

Package Insert: Theophylline THEO2. Roche Corporation 01/2012.

Specimen Requirements

Specimen Type: Plasma
Container/Tube: Mint-green top (lithium heparin)
Specimen Volume: Full tube


Collection Instructions: Draw specimen no earlier than 60 minutes prior to dose. Since absorption is complete by 4 hours, specimens drawn ≥4 hours after the last dose are acceptable.

Day(s) Test Set Up

Monday through Sunday

Turnaround Time:
STAT: 1 hour after receipt in laboratory 
Routine: 2-4 hours after receipt in laboratory

Reference Values

Therapeutic concentrations: 10-20 mcg/mL
Critical result (automatic call-back): ≥25 mcg/mL

Literature Reference:

Waldman SA, Terzic A. Pharmacology and therapeutics, principles to practice. Saunders Elsevier, Philadelphia, PA: 2009.

Test Classification and CPT Coding


Additional Information

For BJH Laboratory Use Only

Alternate Tube(s):

1 dark green-top (lithium or sodium heparin) tube

1 blue-top (sodium citrate) tube

1 lavender-top (EDTA) tube

1 plain, red-top tube
Separator gel tube is acceptable

Analyte Stability:

Specimen should be tested within 2 days of collection if kept at ambient temperature. If specimen must be stored for later testing, store at 2° C to 8° C for up to 7 days or at ≤-20° C for longer periods.

Laboratory Processing Instructions:

Test performed in BJH Core Lab.  Processed by automated line for delivery to the Cobas 8000. Completed specimens are stored refrigerated for 5 days. 

Specimen Transport Temperature


LOINC Code Information

Name LOINC Code
Theophylline, Plasma 4049-3