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Test Code DASM5 Drugs of Abuse Screen, Meconium 5

Reporting Name

Drugs of Abuse Screen, Meconium 5

Useful For

Identifying amphetamines (and methamphetamines), opiates, as well as metabolites of cocaine and marijuana in meconium specimens

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
AMPHM Amphetamines, Confirmation, M Yes No
COKEM Cocaine and Metabolites, Confirm, M Yes No
OPATM Opiate Confirmation, M Yes No
PCPMC PCP Confirmation, Meconium Yes No
THCM Carboxy-THC Confirmation, M Yes No

Testing Algorithm

Testing begins with immunoassay screen. Positives are confirmed and quantitated by liquid chromatography-tandem mass spectrometry (LC-MS/MS) at an additional charge.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Meconium


Specimen Required


Chain of Custody is recommended for this test. Chain-of-Custody Meconium Kit (T653) is available upon request.

 

Container/Tube: Stool container (T288)

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions: Collect entire random meconium specimen.

Additional Information:

1. For chain-of-custody information, see Chain-of-Custody Meconium Kit (T653).

2. Specimen that arrives with a broken seal does not meet the chain-of-custody requirements.

3. The laboratory recommends sending chain-of-custody specimens by overnight shipment.

4. If heroin use is suspected, specimen must be sent frozen to prevent loss of 6-monoacetylmorphine (6MAM, heroin metabolite). When refrigerated, a significant percentage of 6MAM will convert to morphine in <24 hours.


Specimen Minimum Volume

0.45 g (approximately 0.5 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time
Meconium Frozen (preferred) 14 days
  Refrigerated  24 hours

Reference Values

Negative

Positives are reported with a quantitative LC-MS/MS result.

Cutoff concentrations

Amphetamines by ELISA: 100 ng/g

Methamphetamine by ELISA: 100 ng/g

Benzoylecgonine (cocaine metabolite) by ELISA: 100 ng/g

Opiates by ELISA: 100 ng/g

Tetrahydrocannabinol carboxylic acid (marijuana metabolite) by ELISA: 20 ng/g

Phencyclidine by ELISA: 20 ng/g

Day(s) and Time(s) Performed

Monday through Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80307

See individual reflex tests for appropriate CPT codes

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DASM5 Drugs of Abuse Screen, Meconium 5 In Process

 

Result ID Test Result Name Result LOINC Value
32197 Amphetamine 26895-3
32199 Methamphetamine 27289-8
32201 Cocaine 26956-3
32203 Opiate 29158-3
32205 Phencyclidine 26859-9
32207 Tetrahydrocannabinol 26893-8
32208 Chain of Custody No LOINC Needed

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Barnes-Jewish Hospital Additional Information:
For BJH Laboratory Use Only
Laboratory Processing Instructions:

BJH Chemistry will send to St. Louis Children's Hospital core laboratory who will forward to the performing laboratory. Specimen must be received on wet ice.