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Benzodiazepines Screen, Urine

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Methodology

Screen: Kinetic Interaction of Microparticles in Solution (KIMS) 

 

Testing Algorithm:

Samples containing greater than 100 ng/mL of nordiazepam or other cross-reacting substances are reported as screen positive, presumptive.  Results are presumptive for medical purposes only.

 

Literature Reference:

Benzodiazepines ll (BNZ2) package insert, Roche Diagnostics

Specimen Requirements

Specimen Type: Urine, random

Container/Tube: Yellow-top urine collection tube or plain red-top tube (full)

Specimen Volume: 10 mL

Collection Instructions: No additive.

Additional Information: See Urine Collection in Special Instructions for additional information.

 

Day(s) Test Set Up

Monday through Sunday
Turnaround Time:

STAT: Screening result available 1 hour after receipt in laboratory. Confirmation performed within 48 hours.
Routine: Screening result available 3 hours after receipt in laboratory. Confirmation performed within 48 hours.

Test Classification and CPT Coding

80307- Drug screen

80346 - Drug confirmation - Benzodiazepines (if appropriate), (G0480) 

Reference Values

Not detected
Positive screen will be confirmed by LC-MS/MS.

The following drug(s) will be confirmed for positive screen:  alprazolam, clonazepam, flunitrazepam, lorazepam, midazolam, nordiazepam, oxazepam, and temazepam.

Immunoassay screen cut-off level: 100 ng/mL.
Note: Drug results are to be used only for medical purposes. All results, especially unconfirmed screening results, must not be used for non medical purposes.

Specimen Transport Temperature

Ambient

Additional Information

For BJH Laboratory Use Only
Analyte Stability:  

  • Processed sample stability:
    • Ambient - 2 days
    • Refrigerator (2-8°C) - 7 days
    • Frozen (≤-20°C) - 7 days
  • See Analyte Stabiltiy Chart under General Information for a complete list.

Laboratory Processing Instructions:

Test performed in BJH Core Lab.  Processed by automated line for delivery to the Cobas 8000. Completed specimens are stored refrigerated for 5 days.

Special Instructions

LOINC Code Information

Name LOINC Code
Benzodiazepines Screen, Urine 14316-4
Alpha Hydroxyalprazolam (Presence) in Urine by Confirmatory Method 19326-8
7-Aminoclonazepam (Presence) in Urine by Confirmatory Method 58365-8
7-Aminoflunitrazepam (Presence) in Urine by Confirmatory Method 105950-0
Lorazepam (Presence) in Urine by Confirmatory Method 16205-7
1-Hydroxymidazolam (Presence) in Urine by Confirmatory Method 105947-6
Nordiazepam (Presence) in Urine by Confirmatory Method 16202-4
Oxazepam (Presence) in Urine by Confirmatory Method 19639-4
Temazepam (Presence) in Urine by Confirmatory Method 16206-5