Test Code LAB2337 Benzodiazepine Confirmation by Mass Spectrometry
Performing Laboratory
Barnes-Jewish Hospital Laboratory
Methodology
Drug | Cutoff (ng/mL) |
---|---|
Alprazolam Metabolite (Alpha hydroxyalprazolam) | 20 |
Clonazepam Metabolite (7-Aminoclonazepam) | 20 |
Flunitrazepam Metabolite (7-Aminoflunitrazepam) | 20 |
Lorazepam | 20 |
Midazolam Metabolite (1-Hydroxymidazolam) | 100 |
Nordiazepam | 20 |
Oxazepam | 20 |
Temazepam | 20 |
Testing Algorithm:
Results below cutoff are reported as Does Not Confirm.
Results above cutoff are reported as Confirmed Positive.
For drug cutoff information refer to the individual drug analyte.
Confirmatory Method Name:
Liquid Chromatography Tandem Mass Spectrometry
Literature Reference:
See individual test listings.
Specimen Requirements
Specimen Type: Urine, random
Container/Tube: Yellow-top urine collection tube or plain red-top tube (full)
Specimen Volume: 10 mL
Collection Instructions: No additive.
Additional Information: See Urine Collection in Special Instructions for additional information.
Day(s) Test Set Up
Monday through Sunday
Turnaround Time:
STAT: Screening result available 1 hour after receipt in laboratory. Confirmation performed within 48 hours, if applicable.
Routine: Screening result available 3 hours after receipt in laboratory. Confirmation performed within 48 hours, if applicable.
Test Classification and CPT Coding
80307-Drug screen
80346-Drug confirmation- Benzodiazepines (if appropriate) (G0480)
Reference Values
None detected
Specimen Transport Temperature
Ambient
Additional Information
For BJH Laboratory Use Only
Analyte Stability:
- Specimens must be processed within 2 days.
- Processed sample stability:
- Ambient - 2 days
- Refrigerated (2 - 8°C) - 7 days
- Frozen (≤ -20°C) - 7 days
- See Analyte Stability Chart under General Information for a complete list.
Laboratory Processing Instructions:
Test performed in BJH Core Lab. Processed by automated line for delivery to the Cobas 8000 and the Waters LC-MS/MS for confirmation. Completed confirmations are stored frozen for 30 days.
Special Instructions
LOINC Code Information
Name | LOINC Code |
Alpha hydroxyalprazolam | 19326-8 |
7-Aminoclonazepam | 58365-8 |
7-Aminoflunitrazepam | 105950-0 |
Lorazepam | 16205-7 |
1-Hydroxymidazolam | 105947-6 |
Nordiazepam | 16202-4 |
Oxazepam | 19639-4 |
Temazepam | 16206-5 |