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Test Code LAB5565 Cryoglobulin, Serum

Additional Codes

Supplemental Test Code
CRY_S/80988

Reporting Name

Cryoglobulin, S

Useful For

Evaluating cryoglobulins in patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases

 

Evaluating cryoglobulins in patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

 

This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a positive result after 1 or 7 days, then immunofixation will be performed at an additional charge. Positive cryoglobulins of 0.1 mL or above of precipitate will be typed once.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Ordering Guidance


This test is also available as a part of a profile to assess for both cryofibrinogen and cryoglobulin. For more information see CRGSP / Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma.



Specimen Required


Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable. It is very important that the specimen remain at 37° C until after separation of serum from red blood cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require collection and submission a new specimen.


Barnes-Jewish Hospital Note:

Cryoglobulin  
Specimen Type: Serum

Container/Tube: Plain red top

Specimen Volume: 3 full tubes

 

Collection Procedure:
Hospital Patient:
Obtain prewarmed blue, insulated bag from Barnes-Jewish Hospital Chemistry Laboratory or North Campus Laboratory.

1. Draw specimen using 3 red top tubes.
2. Immediately place into prewarmed insulated bag and zip closed immediately.
3. Deliver immediately to Chemistry Laboratory.
Additional Information:

1. Temperature of specimen must be between 32° C to 42° C upon receipt. Specimens not received at proper temperature will be rejected.
2. Analysis cannot be performed with <3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require a new specimen be drawn.
 
Non Hospital Patient:
Call Barnes-Jewish Hospital Laboratory Customer Service at 314-362-1470 prior to collection for processing instructions.

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred)
  Frozen 

Reference Values

Negative (positives reported as percent or trace amount) 

If positive after 1 or 7 days, immunotyping of the cryoprecipitate is performed at an additional charge.

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82595

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRY_S Cryoglobulin, S 12201-0

 

Result ID Test Result Name Result LOINC Value
2684 Cryoglobulin, S 12201-0

Report Available

2 to 10 days

Method Name

CRY_S: Quantitation and Qualitative Typing Precipitation
IMFXC: Immunofixation

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.

Barnes-Jewish Hospital Additional Information:

For BJH Laboratory Use Only

Laboratory Processing Instructions:

BJH Chemistry will forward to the performing laboratory.