Reference Values

0 – 74 yrs: 0 – 300 pg/mL
75 yrs and up: 0 – 450 pg/mL

Interpretive Data

Interpretive Comments:

A. Dyspnea in Acute Care Setting

All Ages: < 300 pg/ml, acute heart failure unlikely

< 50 yrs: ≥ 300 pg/ml and ≤ 450 pg/ml, further investigation warranted

> 450 pg/ml, acute heart failure likely

50 - 74 yrs ≥ 300 pg/ml and ≤ 900 pg/ml, further investigation warranted

> 900 pg/ml, acute heart failure likely

≥ 75 yrs 450 - 1800 pg/ml, further investigation warranted

> 1800 pg/ml, acute heart failure likely

B. Non-acute Setting

< 75 yrs < 125 pg/ml, rules out heart failure

≥ 125 pg/ml, further investigation warranted

≥ 75 yrs < 450 pg/ml, rules out heart failure

≥ 450 pg/ml, further investigation warranted

Knowledge of each individual patient's NT-proBNP range may be more useful than using similar cut-points for every patient.

Please note that marked elevations in NT-proBNP levels may be observed in state other than Left Ventricular Congestive Failure, including: acute coronary syndromes, right heart strain/failure (including pulmonary embolism and cor pulmonale), critial illness, renal failure, as well as advanced age.

References:

1. Januzzi JL et.al. Eur Heart J. 2006:27:330-337.
2. Troughton RW, Richards AM. J. AM Coll Cardiol: Cardiovasc Imag. 2009;2: 216-225.

Interpretive Data Last Revised Date: 8/21/2018.