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Test Code LAB5774 Immunoglobulin Free Light Chains, Serum

Important Note

The instrument for this assay was changed on February 28th, 2024. Use caution, as results may be different across instruments. Patients should be monitored over time using a consistent method and instrumentation.

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Methodology

Profile Information:

Includes kappa free light chain (FLC), lambda FLC, and kappa/lambda FLC ratio. Tests cannot be ordered separately.

Method Name:

Binding Site Optilite tubidimetric

Results from different manufacturers or methods may not be comparable. Serial testing should be performed using the same method.

 

Literature Reference:

Optilite Freelite Kappa Free Kit. Insert Code: INS018.OPT.A version 2nd. October 2018, The Binding Site Group Ltd. 8 Calthrope Road, Edgbaston, Birmingham, B15 1QT, UK

 

Specimen Requirements

Specimen Type: Serum

Container/Tube: Plain red top

Specimen Volume: Full tube

 

Day(s) Test Set Up

Monday through Friday

Cut-off time: 1000

Turnaround Time:
STAT: not available
Routine: results available by 1500 the day of testing

Test Classification and CPT Coding

Test Classification:

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer’s instructions.

CPT Code:

83521 x 2

Reference Values

KAPPA-FREE LIGHT CHAIN

0.33-1.94 mg/dL

 

LAMBDA-FREE LIGHT CHAIN

0.57-2.63 mg/dL

 

KAPPA/LAMBDA FLC RATIO

0.26-1.65

 

Literature Reference:

Katzmann JA, Clark RJ, Abraham RS, et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002;48:1437-44.

Specimen Transport Temperature

Ambient

Additional Information

For BJH Laboratory Use Only
Analyte Stability:

Store specimen at 2° C to 8° C for up to 4 weeks. For prolonged storage, freeze at ≤-20° C. Repeated freeze/thaw cycles should be avoided.

Laboratory Processing Instructions:

Test performed in BJH Core lab.  Processed by automated line and aliquot stored refrigerated for batch analysis.  Completed specimens are stored refrigerated for 5 days.

LOINC Code Information

Name LOINC Code
Kappa/Lambda Free Light Chain Ratio

40844-3