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Test Code LAB6079, LAB874 Cyclosporine, Blood

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Specimen Requirements

Specimen Type: Whole blood

Container/Tube: Lavender top (EDTA)-Separator gel tube is not acceptable.

Specimen Volume: Full tube

 

Collection Instructions:

Do not centrifuge.

1. Draw specimen for trough level immediately prior to next dose.

2. Due to diurnal variations in drug clearance, the same time of day for drawing should be    maintained.

Additional Information:

1. Date and time of draw are required.

2. Indicate trough LAB6079 or random LAB874 on request form.

3. Label specimen appropriately (trough, random).

Day(s) Test Set Up

Monday through Sunday

Cut-off time: 2330, 0600, 0900, 1200, 1530

Turnaround Time:
STAT: not available

Routine: 3 hours after cut-off time

Test Classification and CPT Coding

80158

Reference Values

Results are reported in ng/mL.
The therapeutic range for cyclosporine can vary by transplant organ type and sample timing but a trough range of 100 - 400 ng/mL is typical.

Specimen Transport Temperature

Ambient

Additional Information

For BJH Laboratory Use Only
Alternate Tube:

none

 

Analyte Stability:

  • Specimens must be processed within 7 days.
  • Processed sample stability:
    • Ambient - 7 days
    • Refrigerated (2 - 8°C) - 7 days
    • Frozen (≤ -20°C) - 2 weeks

Mix freshly collected, refrigerated, or thawed specimen thoroughly prior to use. Avoid repeated freezing and thawing.

  • See Analyte Stability Chart under General Information for a complete list.

Laboratory Processing Instructions:

Test performed in BJH Core Lab.  Log in and place in the pending specimen refrigerator. Do not centrifuge. Do not freeze. Completed specimen is stored refrigerated for 5 days.

LOINC Code Information

Name LOINC Code
Cyclosporine 55805-6
Cyclosporine Trough 53828-0