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Test Code Lab5420 Platelet Aggregation

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Methodology

Aggregation

Literature References:

1. Clinical and Laboratory Standards Institute (CLSI). Platelet Function Testing by Aggregometry; Approved Guideline. CLSI document H58-A (ISBN 1-56238-683-2). Clinical and Laboratory Standards Institute, 2008.
2. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 164:927-9.
3. Cattaneo M. Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function. Seminars in Thrombosis and Hemostasis 2009; 35:158-67.
4. Zhou L, Schmaier AH. Platelet aggregation testing in platelet-rich plasma: description of procedures with the aim to develop standards in the field. Am J Clin Pathol 2005;123:172-83.

Specimen Requirements

Performed by special arrangement only. Physician must contact Laboratory Medicine resident at digital pager 314-747-1320 for approval before ordering.

 

Patient Preparation:

Patient must not have taken clopidogrel (Plavix), prasugrel, or other thienopyridines, aspirin, or aspirin-containing compounds for 7 days prior to testing.

 

Specimen Type: Specimen will be drawn by Barnes-Jewish Hospital Hematology staff.

Specimen Minimum Volume: Approximately 20 mL of whole blood

Day(s) Test Set Up

Monday through Friday
Scheduled before 0900

Turnaround Time:
STAT: not available
Routine: results generally available 24 to 36 hours after blood is drawn.

Test Classification and CPT Coding

85576 x 5

Reference Values

Platelet aggregation (ADP, epinephrine, arachidonic acid, collagen, and ristocetin): reported as normal or abnormal

Literature References:

1. Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962;194:927-9.
2. Shattil SJ, Bennett JS. Platelets and their membranes in hemostasis. Physiology and pathophysiology. Ann Int Med 1980;94:10818.

Specimen Transport Temperature

Ambient

Additional Information

For BJH Laboratory Use Only

Analyte Stability:

Must be tested immediately

Laboratory Processing Instructions:

Performed in BJH Core Lab by special arrangement only. Physician must contact Laboratory Medicine resident at digital pager 314-747-1320 for approval before ordering.  If approved, testing will be scheduled with the Special Coagulation supervisor through the LMR.

LOINC Code Information

Name LOINC Code
Arachidonic Acid 49011-0
ADP 49010-2
ADP Aggregation, 1 mcM 49010-2
ADP Aggregation, 3 mcM 49010-2
ADP Aggregation, 5 mcM 49010-2
Collagen, 1 mcg/ml 24379-0
Collagen, 2 mcg/ml 24379-0
Collagen, 5 mcg/ml 24379-0
Epinephrine 5996-4
Epinephrine, 1 mcM 53567-4
Epinephrine, 3 mcM 33530-7
Epinephrine, 5 mcM 33530-7
Ristocetin, 0.6 mg/mL  33533-1
Ristocetin, 1.5 mg/ml 33518-2