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Test Code LAB7045 Cytomegalovirus (CMV) Antibody, IgG and IgM, Serum

Infectious

Performing Laboratory

Barnes-Jewish Hospital Laboratory

Methodology

Multiple Flow Immunoassay

Literature Reference:

 

Package Insert: ToRC IgG package insert, Bio-Rad Laboratories, Inc. 04-2019

Package Insert: ToRC IgM package insert, Bio-Rad Laboratories, Inc. 08-2017

 

Specimen Requirements

Specimen Type: Serum

Container/Tube: Plain red top, Red/Grey SST or Gold SST

Specimen Volume: Full tube

 

Day(s) Test Set Up

Monday through Sunday 0700-1300

Turnaround Time:
STAT: not available
Routine: results available the day of testing

Test Classification and CPT Coding

86644-CMV IgG
86645-CMV IgM

Reference Values

Referenve Values

CMV IgG - Negative

CMV IgM - Negative

Literature Reference:

Henry JB. Clinical diagnosis and management by laboratory methods. 20th ed. Saunders, 2001:765,1046-50,1057-58.

Interpretive Data

CMV IgG

Results

Interpretation

Negative  Negative: Individuals with negative CMV IgG results are presumed to not have had prior exposure or infection with CMV and are, therefore, considered susceptible to primary infection

Equivocal

Equivocal: Equivocal results may occur during acute infection or may be due to nonspecific binding reactions. Submit an additional sample for testing if clinically indicated.

Positive

Positive: Indicates presence of detectable CMV IgG antibody. Results indicate past or recent CMV infection.

 

CMV IgM

Results

Interpretation

Negative

Negative: Negative CMV IgM results suggests that the patient is not experiencing acute or active infection. However, a negative result does not rule-out primary CMV infection.

Equivocal

Equivocal: Equivocal results may occur during acute infection or may be due to nonspecific binding reactions. Submit an additional sample for testing if clinically indicated.

Positive

Positive: Positive CMV IgM results may indicate a recent infection (primary, reactivation, or reinfection).

Notes:

1. Positive results in neonates must be interpreted with caution.
2. Specimens drawn very early in the course of an infection may not have detectable level of IgG. 
3. Patients with immunosuppression or recent blood transfusion must be interpreted with caution.

4. Performance characteristics have not been established for cord blood and neonates.
5. The results obtained from this assay are intended to be an aid to diagnosis only. Each physician must interpret the result in light of the patient’s history, physical findings and other diagnostic procedures.

 

Specimen Transport Temperature

Ambient

Additional Information

For BJH Laboratory Use Only

Alternate Specimen Type: Plasma, mint green (heparin)   

Laboratory Processing Instructions:

Room temperature (18-30° C): 3 days

Refrigerated (2° C to 8° C): 7 days 

Frozen (≤-20° C, no RBCs)

Avoid hemolysis.