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HelpTest Code LAB863 Epstein-Barr Viral Antibody Panel, Serum
Infectious
Performing Laboratory
Barnes-Jewish Hospital Lab
Methodology
Multiplex Flourescent Immunoassay
Testing for Epstein-Barr Viral Capsid IgG, Epstein-Barr Viral Capsid IgM and Epstein-Barr Nuclear Antigen IgG
Literature Reference:
1. EBV IgG and EBV IgM package insert. Bio-Rad Laboratories, Inc. 6/2019
2. Stevens CD.Clinical immunology and serology:a laboratory perspective.2nd ed. Davis, 2003:330-2
3. Henry JB. Clinical diagnosis and management by laboratory methods, 20th ed. Saunders, 2001:593-5, 56-7
4. Straus SE, Cohen JI, Tosato G, Meier J. Epstein-Barr virus infections: biology, pathogenesis and management (NIH Conference), Ann Intern Med 1993; 118:45-58
Specimen Requirements
Specimen Type: Serum only
Container/Tube: Plain red top, Red/grey SST or Gold SST
Specimen Volume: Full tube, minimum 1mL of serum
Day(s) Test Set Up
Monday - Sunday 0700 - 1300
Turnaround Time:
STAT: not available
Routine: result available to day of testing
Test Classification and CPT Coding
86665 Epstein-Barr virus, viral capsid IgG
86665 Epstein-Barr virus, viral capsid IgM
86664 Epstein-Barr virus, nuclear antigen IgG
Reference Values
EBV IgG - Negative
EBV IgM - Negative
EBV NA - Negative
Interpretive Data
EBV IgG
|
Results |
Interpretation |
|
Negative |
No detectable antibody to VCA IgG antibody. |
|
Equivocal |
Uncertain immune status, suggest sending additional specimen. |
|
Positive |
Indicates the presence antibody, 90% of the adult population will have been infected with EBV sometime in the past. |
EBV IgM
|
Negative |
No detectable IgM antibody to EBV-VCA. A negative result indicates no current infection with EBV. If clinical suspician of acute EBV infection is present, testing should be repeated after one week. |
|
Equivocal |
If the sample is equivocal, recommend repeating the test with a second sample within one week. |
|
Positive |
A positive test result indicates a current or reactivated infection with EBV. |
EBV NA
|
Negative |
No detectable IgG antibody to EBV Nuclear Antigen. |
|
Equivocal |
Presence or absence of detectable IgG antibody to EBV Nuclear antigen cannot be determined and the test should be repeated. |
|
Positive |
Indicates the presence of detectable IgG antibody to EBV Nuclear Antigen. |
EBV PANEL Interpretation Algorithm
|
EBV VCA IgG |
EBV VCA IgM |
EBV NA |
Interpretation |
|
Neg |
Neg |
Neg |
No Previous Exposure |
|
Pos |
Pos |
Neg |
Recent Infection |
|
Pos |
Neg |
Pos |
Past Infection |
|
Pos |
Pos |
Pos |
Past Infection |
|
Pos |
Neg |
Neg |
Results indicate infection with EBV at some time (VCA IgG positive). However, the time of the infection cannot be predicted (ie recent or past) since antibodies to EBNA usually develop after primary infection (recent) or, alternatively, approximately 5% to 10% of patients with EBV never develop antibodies to EBNA (past). |
|
All other result combinations including Equivocal. |
Refer to Interp Data for individual antibody results. |
||
Specimen Transport Temperature
Ambient
Additional Information
Laboratory Processing Instructions:
Test performed in BJH Core Laboratory. Specimen will be processed on the automated line for delivery to the AOB rack with a minimum of 1 mL of serum. Completed specimens will be stored 7 days refrigerated.
LOINC Code Information
|
Epstein Barr Virus, VCA IgG |
5157-3 |
|
Epstein Barr Virus, VCA IgM |
5159-9 |
|
Epstein Barr Virus, NA IgG |
30083-0 |